Southern Michigan is the most populated region of the state, so it's no surprise that the most interstate highways crisscross this portion of the state.

Interstates 94 and 96 run west to east and I-69 and I-75 are north-south (until I-69 hits Lansing and changes orientation). Add in I-196 up the lakeshore and you will find nearly all counties in the southern portion of the state have interstate highways.

With just I-75 running north into the tip of the Mitten and eastern Upper Peninsula, there are many, many counties in Northern Michigan without access to an interstate.

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Across southern Michigan, just 5 counties do not have an interstate running through it. First is Cass County, the smallest county in the state by area, I-94 is too far north and east. The Indiana Toll Road (Interstate 80-90) passes just south of the county line.

Neighboring St Joseph County also does not have an interstate. Like Cass, the Indiana Toll Road passes just south and misses the county by just a few feet. Interstate 69 is too far east passing through Branch County.

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To the east of Branch County and I-69, two other southern tier Michigan counties, Hillsdale and Lenawee do not have interstates.

Just one other southern Michigan county without an interstate is Barry County, the home to Hastings and no interstates. Allegan to the west has I-196, Kent and Ionia to the north has I-96 and Kalamazoo and Calhoun to the south have I-94.

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